Cross-cutting guidance

Virtual Issues
17 November 2017
1 February 2024
Guidance of the Scientific Committee/EFSA on broad assessment principles (e.g. uncertainty analysis, statistical reporting, structure of outputs) that apply to all or most of EFSA's scientific assessments.
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Guidance documents

Open Access

Guidance on protocol development for EFSA generic scientific assessments

EFSA Scientific Committee (SC) ,  Simon More,  Vasileios Bampidis,  Diane Benford,  Claude Bragard,  Antonio Hernández-Jerez,  Susanne Hougaard Bennekou,  Konstantinos Panagiotis Koutsoumanis,  Claude Lambré,  Kyriaki Machera,  Ewen Mullins,  Søren Saxmose Nielsen,  Josef Schlatter,  Dieter Schrenk,  Dominique Turck,  Maged Younes,  Andrew Kraft,  Hanspeter Naegeli,  Katya Tsaioun,  Elisa Aiassa,  Davide Arcella,  Fulvio Barizzone,  Maeve Cushen,  Marios Georgiadis,  Andrea Gervelmeyer,  Anna Lanzoni,  Paolo Lenzi,  Federica Lodi,  Laura Martino,  Winy Messens,  Luisa Ramos Bordajandi,  Valentina Rizzi,  Giuseppe Stancanelli,  Špela Supej,  Thorhallur Ingi Halldorsson, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2022.EN-7349/full

Open Access

Guidance on aneugenicity assessment

EFSA Scientific Committee (SC) ,  Simon John More,  Vasileios Bampidis,  Claude Bragard,  Thorhallur Ingi Halldorsson,  Antonio F Hernández-Jerez,  Susanne Hougaard Bennekou,  Kostas Koutsoumanis,  Claude Lambré,  Kyriaki Machera,  Hanspeter Naegeli,  Søren Saxmose Nielsen,  Josef Schlatter,  Dieter Schrenk,  Dominique Turck,  Maged Younes,  Gabriele Aquilina,  Margherita Bignami,  Claudia Bolognesi,  Riccardo Crebelli,  Rainer Gürtler,  Francesca Marcon,  Elsa Nielsen,  Christiane Vleminckx,  Maria Carfì,  Carla Martino,  Daniela Maurici,  Juan Parra Morte,  Annamaria Rossi,  Diane Benford, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2021.EN-6814/full

Open Access

Guidance on technical requirements for regulated food and feed product applications to establish the presence of small particles including nanoparticles

EFSA Scientific Committee ,  Simon More,  Vasileios Bampidis,  Diane Benford,  Claude Bragard,  Thorhallur Halldorsson,  Antonio Hernández-Jerez,  Susanne Hougaard Bennekou,  Kostas Koutsoumanis,  Claude Lambré,  Kyriaki Machera,  Hanspeter Naegeli,  Søren Nielsen,  Josef Schlatter,  Dieter Schrenk,  Vittorio Silano (deceased),  Dominique Turck,  Maged Younes,  Jacqueline Castenmiller,  Qasim Chaudhry,  Francesco Cubadda,  Roland Franz,  David Gott,  Jan Mast,  Alicja Mortensen,  Agnes G. Oomen,  Stefan Weigel,  Eric Barthelemy,  Ana Rincon,  Jose Tarazona,  Reinhilde Schoonjans, 

This publication is linked to the following EFSA Journal article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/j.efsa.2021.6768/full

This publication is linked to the following EFSA Supporting Publications articles: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2021.EN-6804/full, http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2021.EN-6502/full

Open Access

Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health

EFSA Scientific Committee ,  Simon More,  Vasileios Bampidis,  Diane Benford,  Claude Bragard,  Thorhallur Halldorsson,  Antonio Hernández-Jerez,  Susanne Hougaard Bennekou,  Kostas Koutsoumanis,  Claude Lambré,  Kyriaki Machera,  Hanspeter Naegeli,  Søren Nielsen,  Josef Schlatter,  Dieter Schrenk,  Vittorio Silano (deceased),  Dominique Turck,  Maged Younes,  Jacqueline Castenmiller,  Qasim Chaudhry,  Francesco Cubadda,  Roland Franz,  David Gott,  Jan Mast,  Alicja Mortensen,  Agnes G. Oomen,  Stefan Weigel,  Eric Barthelemy,  Ana Rincon,  José Tarazona,  Reinhilde Schoonjans, 

This publication is linked to the following EFSA Journal article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/j.efsa.2021.6769/full

This publication is linked to the following EFSA Supporting Publications articles: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2021.EN-6502/full, http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2020.EN-1948/full

Open Access

Draft for internal testing Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments

EFSA Scientific Committee ,  Simon More,  Vasileos Bambidis,  Diane Benford,  Claude Bragard,  Antonio Hernandez-Jerez,  Susanne Hougaard Bennekou,  Kostas Koutsoumanis,  Kyriaki Machera,  Hanspeter Naegeli,  Soren Saxmose Nielsen,  Josef R Schlatter,  Dieter Schrenk,  Vittorio Silano,  Dominique Turck,  Maged Younes,  Tony Fletcher,  Matthias Greiner,  Evangelia Ntzani,  Neil Pearce,  Marco Vinceti,  Laura Ciccolallo,  Marios Georgiadis,  Andrea Gervelmeyer,  Thorhallur I Halldorsson, 
Open Access

Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment

EFSA Scientific Committee ,  Simon J More,  Vasileios Bampidis,  Diane Benford,  Claude Bragard,  Thorhallur I Halldorsson,  Antonio F Hernández-Jerez,  Susanne Hougaard Bennekou,  Kostas P Koutsoumanis,  Kyriaki Machera,  Hanspeter Naegeli,  Søren S Nielsen,  Josef R Schlatter,  Dieter Schrenk,  Vittorio Silano,  Dominique Turck,  Maged Younes,  Ursula Gundert-Remy,  George E N Kass,  Juliane Kleiner,  Anna Maria Rossi,  Rositsa Serafimova,  Linda Reilly,  Heather M Wallace, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2019.EN-1661/full

Open Access

Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals

EFSA Scientific Committee ,  Simon John More,  Vasileios Bampidis,  Diane Benford,  Susanne Hougaard Bennekou,  Claude Bragard,  Thorhallur Ingi Halldorsson,  Antonio F Hernández-Jerez,  Konstantinos Koutsoumanis,  Hanspeter Naegeli,  Josef R Schlatter,  Vittorio Silano,  Søren Saxmose Nielsen,  Dieter Schrenk,  Dominique Turck,  Maged Younes,  Emilio Benfenati,  Laurence Castle,  Nina Cedergreen,  Anthony Hardy,  Ryszard Laskowski,  Jean Charles Leblanc,  Andreas Kortenkamp,  Ad Ragas,  Leo Posthuma,  Claus Svendsen,  Roland Solecki,  Emanuela Testai,  Bruno Dujardin,  George EN Kass,  Paola Manini,  Maryam Zare Jeddi,  Jean-Lou CM Dorne,  Christer Hogstrand, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2019.EN-1589/full, http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2019.EN-1602/full

Open Access

Genotoxicity assessment of chemical mixtures

EFSA Scientific Committee ,  Simon More,  Vasileios Bampidis,  Diane Benford,  Jos Boesten,  Claude Bragard,  Thorhallur Halldorsson,  Antonio Hernandez-Jerez,  Susanne Hougaard-Bennekou,  Kostas Koutsoumanis,  Hanspeter Naegeli,  Søren Saxmose Nielsen,  Dieter Schrenk,  Vittorio Silano,  Dominique Turck,  Maged Younes,  Gabriele Aquilina,  Riccardo Crebelli,  Rainer Gürtler,  Karen Ildico Hirsch-Ernst,  Pasquale Mosesso,  Elsa Nielsen,  Roland Solecki,  Maria Carfì,  Carla Martino,  Daniela Maurici,  Juan Parra Morte,  Josef Schlatter, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2019.EN-1539/full

Open Access

Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health

EFSA Scientific Committee ,  Anthony Hardy,  Diane Benford,  Thorhallur Halldorsson,  Michael John Jeger,  Helle Katrine Knutsen,  Simon More,  Hanspeter Naegeli,  Hubert Noteborn,  Colin Ockleford,  Antonia Ricci,  Guido Rychen,  Josef R. Schlatter,  Vittorio Silano,  Roland Solecki,  Dominique Turck,  Maged Younes,  Qasim Chaudhry,  Francesco Cubadda,  David Gott,  Agnes Oomen,  Stefan Weigel,  Melpo Karamitrou,  Reinhilde Schoonjans,  Alicja Mortensen, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2018.EN-1430/full

Open Access

Clarification of some aspects related to genotoxicity assessment

EFSA Scientific Committee ,  Anthony Hardy,  Diane Benford,  Thorhallur Halldorsson,  Michael Jeger,  Helle Katrine Knutsen,  Simon More,  Hanspeter Naegeli,  Hubert Noteborn,  Colin Ockleford,  Antonia Ricci,  Guido Rychen,  Vittorio Silano,  Roland Solecki,  Dominique Turck,  Maged Younes,  Gabriele Aquilina,  Riccardo Crebelli,  Rainer Gürtler,  Karen Ildico Hirsch-Ernst,  Pasquale Mosesso,  Elsa Nielsen,  Jan van Benthem,  Maria Carfì,  Nikolaos Georgiadis,  Daniela Maurici,  Juan Parra Morte,  Josef Schlatter, 
Open Access

Guidance on Uncertainty Analysis in Scientific Assessments

EFSA Scientific Committee ,  Diane Benford,  Thorhallur Halldorsson,  Michael John Jeger,  Helle Katrine Knutsen,  Simon More,  Hanspeter Naegeli,  Hubert Noteborn,  Colin Ockleford,  Antonia Ricci,  Guido Rychen,  Josef R Schlatter,  Vittorio Silano,  Roland Solecki,  Dominique Turck,  Maged Younes,  Peter Craig,  Andrew Hart,  Natalie Von Goetz,  Kostas Koutsoumanis,  Alicja Mortensen,  Bernadette Ossendorp,  Laura Martino,  Caroline Merten,  Olaf Mosbach-Schulz,  Anthony Hardy, 

This publication is linked to the following EFSA Journal article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/j.efsa.2018.5122/full

Open Access

Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age

EFSA Scientific Committee ,  Anthony Hardy,  Diane Benford,  Thorhallur Halldorsson,  Michael John Jeger,  Helle Katrine Knutsen,  Simon More,  Hanspeter Naegeli,  Hubert Noteborn,  Colin Ockleford,  Antonia Ricci,  Guido Rychen,  Josef R Schlatter,  Vittorio Silano,  Roland Solecki,  Dominique Turck,  Jean-Louis Bresson,  Birgit Dusemund,  Ursula Gundert-Remy,  Mathilde Kersting,  Claude Lambré,  André Penninks,  Angelika Tritscher,  Ine Waalkens-Berendsen,  Ruud Woutersen,  Davide Arcella,  Daniele Court Marques,  Jean-Lou Dorne,  George EN Kass,  Alicja Mortensen, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2017.EN-1248/full

Open Access

Guidance on the use of the weight of evidence approach in scientific assessments

EFSA Scientific Committee ,  Anthony Hardy,  Diane Benford,  Thorhallur Halldorsson,  Michael John Jeger,  Helle Katrine Knutsen,  Simon More,  Hanspeter Naegeli,  Hubert Noteborn,  Colin Ockleford,  Antonia Ricci,  Guido Rychen,  Josef R Schlatter,  Vittorio Silano,  Roland Solecki,  Dominique Turck,  Emilio Benfenati,  Qasim Mohammad Chaudhry,  Peter Craig,  Geoff Frampton,  Matthias Greiner,  Andrew Hart,  Christer Hogstrand,  Claude Lambre,  Robert Luttik,  David Makowski,  Alfonso Siani,  Helene Wahlstroem,  Jaime Aguilera,  Jean-Lou Dorne,  Antonio Fernandez Dumont,  Michaela Hempen,  Silvia Valtueña Martínez,  Laura Martino,  Camilla Smeraldi,  Andrea Terron,  Nikolaos Georgiadis,  Maged Younes, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2017.EN-1295/full

Open Access

Guidance on the assessment of the biological relevance of data in scientific assessments

EFSA Scientific Committee ,  Anthony Hardy,  Diane Benford,  Thorhallur Halldorsson,  Michael John Jeger,  Helle Katrine Knutsen,  Simon More,  Hanspeter Naegeli,  Hubert Noteborn,  Colin Ockleford,  Antonia Ricci,  Guido Rychen,  Josef R Schlatter,  Vittorio Silano,  Roland Solecki,  Dominique Turck,  Maged Younes,  Jean-Louis Bresson,  John Griffin,  Susanne Hougaard Benekou,  Henk van Loveren,  Robert Luttik,  Antoine Messean,  André Penninks,  Giuseppe Ru,  Jan Arend Stegeman,  Wopke van der Werf,  Johannes Westendorf,  Rudolf Antonius Woutersen,  Fulvio Barizzone,  Bernard Bottex,  Anna Lanzoni,  Nikolaos Georgiadis,  Jan Alexander, 

This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2017.EN-1296/full

Open Access

Update: use of the benchmark dose approach in risk assessment

EFSA Scientific Committee ,  Anthony Hardy,  Diane Benford,  Thorhallur Halldorsson,  Michael John Jeger,  Katrine Helle Knutsen,  Simon More,  Alicja Mortensen,  Hanspeter Naegeli,  Hubert Noteborn,  Colin Ockleford,  Antonia Ricci,  Guido Rychen,  Vittorio Silano,  Roland Solecki,  Dominique Turck,  Marc Aerts,  Laurent Bodin,  Allen Davis,  Lutz Edler,  Ursula Gundert-Remy,  Salomon Sand,  Wout Slob,  Bernard Bottex,  Jose Cortiñas Abrahantes,  Daniele Court Marques,  George Kass,  Josef R. Schlatter, 

http://onlinelibrary.wiley.com.ezproxyberklee.flo.org/doi/10.2903/sp.efsa.2017.EN-1147/full

Open Access

Guidance to develop specific protection goals options for environmental risk assessment at EFSA, in relation to biodiversity and ecosystem services

EFSA Scientific Committee , 
Open Access

Guidance on Statistical Reporting

European Food Safety Authority , 
Open Access

Explanatory statement for the applicability of the Guidance of the EFSA Scientific Committee on conducting repeated-dose 90-day oral toxicity study in rodents on whole food/feed for GMO risk assessment

European Food Safety Authority , 
Open Access

Guidance on the structure and content of EFSA's scientific opinions and statements

EFSA Scientific Committee , 
Open Access

Guidance on Expert Knowledge Elicitation in Food and Feed Safety Risk Assessment

European Food Safety Authority ,